Gene information
Official symbol NOS2
Official full name nitric oxide synthase 2
Gene type protein-coding gene
Chromosome17q11.2
Alias symboliNOS; NOS; HEP-NOS
Previous symbolNOS2A
Resources
Entrez Gene 4843
HGNC HGNC:7873
Ensembl ENSG00000007171
Vega OTTHUMG00000132445
UCSC uc002gzu.4
GO terms: 62 records
GO Description Category LogP Number of genes Detail
GO:0001666 response to hypoxia GO Biological Processes -40.6131384 77 More
GO:0001912 positive regulation of leukocyte mediated cytotoxicity GO Biological Processes -3.17989306 9 More
GO:0002237 response to molecule of bacterial origin GO Biological Processes -48.4964960 93 More
GO:0002251 organ or tissue specific immune response GO Biological Processes -5.08329154 5 More
GO:0002385 mucosal immune response GO Biological Processes -2.67022626 3 More
GO:0003013 circulatory system process GO Biological Processes -65.2875605 130 More
GO:0005938 cell cortex GO Cellular Components -2.49954036 24 More
GO:0006140 regulation of nucleotide metabolic process GO Biological Processes -7.41911571 18 More
GO:0006525 arginine metabolic process GO Biological Processes -5.72938190 7 More
GO:0006801 superoxide metabolic process GO Biological Processes -5.35296451 10 More
GO:0008015 blood circulation GO Biological Processes -65.7270163 119 More
GO:0008217 regulation of blood pressure GO Biological Processes -35.2019435 60 More
GO:0009064 glutamine family amino acid metabolic process GO Biological Processes -4.49369376 12 More
GO:0009065 glutamine family amino acid catabolic process GO Biological Processes -3.31496494 6 More
GO:0009410 response to xenobiotic stimulus GO Biological Processes -32.6021211 82 More
GO:0009725 response to hormone GO Biological Processes -49.1091700 138 More
GO:0009895 negative regulation of catabolic process GO Biological Processes -10.3621088 43 More
GO:0010942 positive regulation of cell death GO Biological Processes -48.7037743 123 More
GO:0016597 amino acid binding GO Molecular Functions -2.64811100 8 More
GO:0019725 cellular homeostasis GO Biological Processes -21.1508273 85 More
GO:0019932 second-messenger-mediated signaling GO Biological Processes -19.1717114 46 More
GO:0023061 signal release GO Biological Processes -5.50151396 21 More
GO:0031343 positive regulation of cell killing GO Biological Processes -3.44182824 10 More
GO:0031406 carboxylic acid binding GO Molecular Functions -5.96500660 23 More
GO:0032496 response to lipopolysaccharide GO Biological Processes -45.257773 87 More
GO:0032675 regulation of interleukin-6 production GO Biological Processes -28.2553997 51 More
GO:0032677 regulation of interleukin-8 production GO Biological Processes -20.0046302 33 More
GO:0032755 positive regulation of interleukin-6 production GO Biological Processes -18.6559032 31 More
GO:0032940 secretion by cell GO Biological Processes -8.42144465 43 More
GO:0034341 response to interferon-gamma GO Biological Processes -10.8524889 26 More
GO:0036293 response to decreased oxygen levels GO Biological Processes -40.9544531 79 More
GO:0042803 protein homodimerization activity GO Molecular Functions -14.2815375 77 More
GO:0043068 positive regulation of programmed cell death GO Biological Processes -46.5713594 114 More
GO:0043177 organic acid binding GO Molecular Functions -5.71225789 20 More
GO:0043457 regulation of cellular respiration GO Biological Processes -4.43542328 10 More
GO:0043467 regulation of generation of precursor metabolites and energy GO Biological Processes -10.8295915 27 More
GO:0045776 negative regulation of blood pressure GO Biological Processes -17.1357953 22 More
GO:0045981 positive regulation of nucleotide metabolic process GO Biological Processes -9.35726225 15 More
GO:0046903 secretion GO Biological Processes -18.5147167 70 More
GO:0048471 perinuclear region of cytoplasm GO Cellular Components -8.50169248 66 More
GO:0048511 rhythmic process GO Biological Processes -10.3377021 38 More
GO:0050660 flavin adenine dinucleotide binding GO Molecular Functions -1.96545001 9 More
GO:0050661 NADP binding GO Molecular Functions -1.63389635 6 More
GO:0050708 regulation of protein secretion GO Biological Processes -30.3716714 63 More
GO:0051046 regulation of secretion GO Biological Processes -54.0079540 130 More
GO:0051223 regulation of protein transport GO Biological Processes -25.2801266 81 More
GO:0062012 regulation of small molecule metabolic process GO Biological Processes -26.8746473 69 More
GO:0062013 positive regulation of small molecule metabolic process GO Biological Processes -17.9792910 37 More
GO:0070201 regulation of establishment of protein localization GO Biological Processes -24.4831554 82 More
GO:0070482 response to oxygen levels GO Biological Processes -40.7566635 82 More
GO:0071216 cellular response to biotic stimulus GO Biological Processes -28.1549742 59 More
GO:0071219 cellular response to molecule of bacterial origin GO Biological Processes -28.3848077 56 More
GO:0071222 cellular response to lipopolysaccharide GO Biological Processes -26.0381191 52 More
GO:0071396 cellular response to lipid GO Biological Processes -37.0669488 98 More
GO:0071466 cellular response to xenobiotic stimulus GO Biological Processes -9.33788411 28 More
GO:0072593 reactive oxygen species metabolic process GO Biological Processes -9.21564496 21 More
GO:0140352 export from cell GO Biological Processes -8.94733589 48 More
GO:1900015 regulation of cytokine production involved in inflammatory response GO Biological Processes -18.8349263 16 More
GO:1900542 regulation of purine nucleotide metabolic process GO Biological Processes -7.57719972 18 More
GO:1900544 positive regulation of purine nucleotide metabolic process GO Biological Processes -9.35726225 15 More
GO:1901605 alpha-amino acid metabolic process GO Biological Processes -2.81275840 18 More
GO:1903530 regulation of secretion by cell GO Biological Processes -45.6472055 114 More
KEGG pathways: 3 records
KEGG Description Category LogP Number of genes Detail
hsa00220 Arginine biosynthesis KEGG Pathway -6.91942497 9 More
hsa04020 Calcium signaling pathway KEGG Pathway -10.4415222 36 More
hsa05200 Pathways in cancer KEGG Pathway -30.6393212 92 More
Drug-Gene interaction
view
Related drugs: 21 records
Drug name Interaction type Source PMID View
alt-2074 TTD view
banoxantrone DTC 18681417 view
benzodiazepine NCI 12106778 view
captopril NCI 15680268 view
curcumin TTD view
diazoxide NCI 12856829 view
dimethyl sulfoxide NCI 15919216 view
doxorubicin PharmGKB 21048526 view
doxycycline inhibitor MyCancerGenomeClinicalTrial view
estradiol NCI 17068060 view
fluoxetine NCI 16413968 view
gw-274150 inhibitor TTD view
ibuprofen PharmGKB 25502615 view
isoniazid PharmGKB 22341855 view
kd7040 TdgClinicalTrial view
nimodipine NCI 16044358 view
pimagedine inhibitor TTD 10592235117523521713928417016423 view
propofol NCI 16645450 view
rifampin PharmGKB 22341855 view
theophylline NCI 12223230 view
tilarginine TdgClinicalTrial view
Related study: 1 record
Molecular factor Omics type Application Objective MI type Reference
NOS2 transcriptomics myocardial infarction[diagnosis] myocardial infarction Wilmes V et al. Int J Legal Med. 2019
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